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Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: A double-blind placebo-controlled randomized trial

dc.contributor.authorKirwan, Patrick
dc.contributor.authorJackson, Andrew L
dc.contributor.authorAsaolu, Samuel O
dc.contributor.authorMolloy, Sile F
dc.contributor.authorAbiona, Titilayo C
dc.contributor.authorBruce, Marian C
dc.contributor.authorCartwright, Lisa Ranford
dc.contributor.authorNeill, Sandra M O’
dc.contributor.authorHolland, Celia V
dc.date.accessioned2020-02-07T13:22:26Z
dc.date.available2020-02-07T13:22:26Z
dc.date.issued2010-09
dc.identifier.otherDOI: 10.1186/1471-2334-10-277
dc.identifier.urihttps://ir.oauife.edu.ng/handle/123456789/5159
dc.description BMC Infectious Diseases ,NO.10,PG.1-11en_US
dc.description.abstractBackground: Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children. Methods: A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plasmodium infection in children aged 12-59 months. Children were randomly assigned to receive either albendazole or placebo every four months for 12 months with a follow-up at 14 months. Results: 320 children (out of 1228, 26.1%) complied with all the follow-up assessments. Plasmodium prevalence and mean Plasmodium parasite density was significantly higher in the treatment group (44.9% and 2319 ± SE 511) compared to the placebo group (33.3% and 1471 ± 341) at baseline. The odds of having Plasmodium infection increased over time for children in both the placebo and treatment groups, however this increase was significantly slower for children in the treatment group (P = 0.002). By month 14, mean Plasmodium density had increased by 156% in the placebo group and 98% in the treatment group but the rate of change in Plasmodium density was not significantly different between the groups. The change from baseline in haemoglobin had a steeper increase among children in the treatment group when compared to the placebo group but this was not statistically significant. Conclusions: Repeated four-monthly anthelminthic treatments for 14 months resulted in a significantly lower increase in the prevalence of Plasmodium infection in preschool children which coincided with a reduction in both the prevalence and intensity of A. lumbricoides infections. Trial Registration: Current controlled trials ISRCTN44215995en_US
dc.language.isoenen_US
dc.publisherKirwan et al. BMC Infectious Diseasesen_US
dc.subjectalbendazoleen_US
dc.subjectlumbricoides infectionsen_US
dc.subjectPlasmodium infectionsen_US
dc.subjectplacebo-controlled randomised trialen_US
dc.subjectPlasmodium parasite densityen_US
dc.titleImpact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: A double-blind placebo-controlled randomized trialen_US
dc.title.alternativea double-blind placebo-controlled randomized trialen_US
dc.typeJournalen_US


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