Department of Biochemistry and Molecular Biology

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Department of Biochemistry

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Browsing Department of Biochemistry and Molecular Biology by Author "Aboderin, A."

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    Archachatina (Calachatina) Marginata Haemolymph Proteins, Physicochemical Characterization of Protein B.
    (Obafemi Awolowo University, 1985) Binutu, Olaoluwa Olujare; Aboderin, A.
    The haemolymph of Archachatina (Calachatina) marginata has been found to contain other proteins apart from the predominant protein, haemocyanin. One of the other protein components, Protein B, was isolated and purified using preparatory ultracentrifugation and gel filtration techniques. Physicochemical characterization, employing different techniques has showed that Protein B is different from the haemocyanin (and/or its subunit(s)) from this mollusc. Protein B has a molecular weight of 360KD consisting of two chains which are of identical molecular size. Amino acid composition for Protein B shows that: (i) there exist more acidic residues combined than those of the basic residues combined. (ii) there is a very large occurence of Proline residues (iii) there is also a large amount of cysteine residues. There is one gram atom of copper per dimer. Protein B is a glycoprotein. The carbohydrate portion is made up of units of acetylglucosamine and galactosamine. Peptic peptide fractionation of reduced carboxymethylated Protein B has shown that most of the carbohydrate can be found on a peptide having a mass of 15KD.
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    Proteins, Nature's Versatile Devices
    (Obafemi Awolowo University Press, 1981-02-17) Aboderin, A.
    It is our intentions in this lecture to explore some of the unities that characterise life from the intellectual niche of the protein molecule. To the extent that it can be demonstrated that the choice is not a parochial one, but one that belongs, if not at the centre, close to the centre of the phenomenon of life, to that extent will the intention of this discourse have been fulfilled. As is usual in this type of setting however it is fit and proper for me to seek the understanding of both the initiates and the laity, obviously for very different but understandable reasons. Proteins, as nature's versatile devices, function within comparatively macroscopic entities known as cells. As all students of biology and the history of biology are aware, the cell is the basic unit of biological life. As everyone again is aware there are different kinds of cells, In multicellular organisms such as the present lecture, there are brain cells, liver cells, kidney cells, all of which, within the proper observational grid, not only look different but also have different properties and functions.