The effect of histamine iontophoresis on the heart rate and blood pressure of female subjects
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Date
2004-04
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Abstract
The main purpose of this study was to determine the effect of
histamine iontophoresis on the Blood Pressure (BP), and heart
rate (HR) of female subjects. Twenty apparently healthy female
undergraduates of Obafemi Awolowo University, Ile-Ife
(average age 24.2 ± 2.9) participated in the study. An automated
electronic sphygmo-manometer that monitors both BP
and HR was used to measure the Systolic Blood Pressure(SBP)
and diastolic Blood Pressure (DBP) over the left brachial artery.
The histamine gel used in this study contained I percent
histamine dihydro-chloride. The gel was applied to the right
biceps brachii and active was applied below the cubital fossa.
The current intensity Interrupted Direct Current (IDC) was
gradually increased and subjects were instructed to indicate
immediately they experienced tingling sensation under the electrode.
The same procedure was carried out the second time on
the subjects with the same intensity of IDC current but without
histamine for each subject. The treatments were administered
on different days but within a two-week interval. The
cardiovascular response was monitored five minutes before
the administration, twenty minutes during the administration
and five minutes after the termination of each treatment. Blood
Pressure and heart rate did not change significantly from the
baseline during the histamine iontophoresis and direct currents
treatments (P > 0.05). The findings suggest that the subjects
BP and HR were not affected by histamine iontophoresis
during the twenty minutes treatment. It was concluded
that local administration of I per cent histamine dihydrochloride
into the subcutaneous tissue of females' right upper arm with
the aid of direct current did not appreciably affect the blood
pressure and heart rate after 20 minutes of treatment.
Description
p5
Keywords
Iontophoresis, histamine, heart rate, blood pressure
Citation
Adedoyin, Rufus & Olaogun, Matthew & E Ukponmwan, O & Orafidiya, Lara (Omolara. (2004). The effect of histamine iontophoresis on the heart rate and blood pressure of female subjects. African journal of medicine and medical sciences. 33. 5-9.