Browsing by Author "Agbonkhese, Christopher"

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    Development of a Dosage Model for the Management of Sickle Cell Anaemia in African Traditional Medicine
    (Obafemi Awolowo University, 2015) Agbonkhese, Christopher
    This study developed a dosage model for the management of patients with Sickle Cell Anaemia (SCA) in African Traditional Medicine (ATM), and simulated the model. It also evaluated the model for consistency. This was with a view to ensuring correct dose precision for proper management of patients suffering from sickle cell disorder. Interview-driven questionnaires were used to collect data on the management of SCA from forty Traditional Medical Practitioners. The data were analyzed using SPSS. The Dosage Model was designed using Unified Modeling Language (UML), while Fuzzy Logic was used to design its intelligence. The Mass Of Recipe (MOR) and Volume Of Solvent (VOS) were used as inputs for the Fuzzy Inference System (FIS), and the output of the model was computed using the dilution equation (M1V1=M2V2). The model was simulated in order to observe its behaviour for some given inputs using Matlab, and evaluated by comparing fuzzy output with TMPs prescriptions to ensure consistency. Results from the analysis revealed that three major herbal formulas were used by the TMPs (formula A, formula B, and formula C). ‘Formula A’ consist mainly of Lawsonia inermi, ‘formula B’ consist of Zanthozylum zanthoxyloids, and ‘formula C’ consist of Adansonia digitata. Simulation of the model gave a dose of 118 ml for adults and 59 ml for children on an average concentration of 74.4g/L of Lawsonia inermi for ‘formula A’, 148 ml for adults and 74 ml for children on an average concentration of 75.4g/L of Zanthozylum zanthoxyloids for ‘formula B’, 150 ml for adults and 75 ml for children on an average concentration of 71.1g/L of Adansonia digitata for ‘formula C’ respectively. Evaluation of the model showed the FIS output doses to be consistent with the TMPs prescriptions, since these values lied between the maximum and minimum TMPs prescription of 152 ml and 113 ml for adult dose, 80 ml and 59 ml for children dose using ‘formula A’, 248 ml and 85 ml for adults, 131 ml and 47 ml for children using ‘formula B’, 204 ml and 118 ml for adults, 102 ml and 59 ml for children, using ‘formula C. This implied that the same concentration of herbal solution could be used for prescribing different doses, using any of the three formulas to ensure precision. The study concluded that Fuzzy Logic techniques can be used to determine the dose of herbal medicine precisely.