Browsing by Author "Akinwumi, Florence Olubunmi"

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    A study of antibiotic resistance profile of diarrhoeagenic pathogens isolated from infected children in Ile-Ife
    (Obafemi Awolowo University, 2015) Akinwumi, Florence Olubunmi
    This study identified the bacterial pathogens associated with diarrhoea in children aged 0-24 months, established the frequency of diarrhoea caused by each pathogen encountered in diarrhoea and determined the antibiotic resistance pattern of the children's faecal isolates obtained to some commonly used antibiotics. This was with a view to providing information on the aetiology and management of diarrhoea in Ile-Ife, South West, Nigeria. A total of 107 children within the age range 0-24 months presenting with diarrhoea and 115 apparently healthy children (aged 0-24 months) receiving immunization at the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Eleyele and State Hospital, Okeogbo both in Ile-Ife were recruited into this study. Stool samples or rectal swabs were collected using sterile swab sticks and sterile universal bottles. These samples were cultured for the isolation of enteric pathogens present in the stool using standard microbiological procedures. All recovered isolates were tested against 8 antibiotics using the disc diffusion method. Data were analysed by descriptive and inferential statistics. The isolation of enteric pathogens was found to be significantly (p<0.0001) higher among diarrhoeal children (388) than among the apparently healthy children who did not exhibit symptoms of diarrhoea (279). Children in the age group 13-18 months were mostly affected by diarrhoea diseases. Campylobacter spp. was the most frequently isolated enteric pathogen among diarrhoeal (17.8%) and apparently healthy (16.5%) children. There was no significant (p > 0.05) difference in the isolates recovered from both diarrhoeal and control subjects. The isolates were found to be multiply resistant to all the antibiotics tested. However, the incidence of resistance to ciprofloxacin, gentamicin, ceftriaxone and chloramphenicol was less than 50%. The study concluded that more than one enteric pathogen may be responsible for diarrhoea diseases in a single patient and that the pathogens encountered were resistant to the antibiotics which were frequently administered to patients within the study