A comparative biochemical study of the interaction of some trypanocides with rat tissue cellular systems

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dc.contributor.authorAkanji, Musbau Adewumi
dc.contributor.otherEdwin.O. Ngaha, J.O. Folahan
dc.coverage.geographicalNigeriaen_US
dc.date.accessioned2013-08-19T14:51:43Z
dc.date.accessioned2018-10-29T10:55:57Z
dc.date.available2013-08-19T14:51:43Z
dc.date.available2018-10-29T10:55:57Z
dc.date.issued1986
dc.degree.awardPhDen_US
dc.departmentBiochemistryen_US
dc.description.abstractThe effects of three trypanocides (tryparsamide, novidium and berenil) on rat liver and kidney were studied with a view to understanding the site of primary injury to the cell resulting from their administration. Four enzymes which are exclusively located in specific regions of the cell were used to monitor the regions affected by the drugs. The results obtained showed that administration of each of the three drugs resulted in massive increase of alkaline phosphates activity and a very marked inhibition of lactate dehydrogenase activity in both tissues. There was no significant effect on the lysosomal enzymes both in vivo and in vitro. These results indicate that tryparsamide, novidium and berenil ellicit their action on the cellular system of both liver and kidney in similar ways when administered to rats. Inhibition of lactate dehydrogenase activity which is located in the soluble fraction of cytoplasm may lead to accumulation of pyruvate in the cell. The massive increase of alkaline phosphates activity in the tissues may also lead to indiscriminate hydrolysis of phosphate esters needed for vital activities in the cell.en_US
dc.facultiesScienceen_US
dc.format.filetypePDFen_US
dc.identifier.citationAkanji, Musbau Adewumi (1986) A comparative biochemical study of the interaction of some trypanocides with rat tissue cellular systems. Ph.D. Biochemistry, Ile-Ife: OAUen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/3294
dc.language.isoenen_US
dc.pages.totalpages204en_US
dc.publisherObafemi Awolowo University, Ile Ife, Nigeriaen_US
dc.subjectIndiscrimainate Hydrolysisen_US
dc.subjectPhosphate Estersen_US
dc.subjectTrypanocidesen_US
dc.subjectLactate Dehydrogenaseen_US
dc.titleA comparative biochemical study of the interaction of some trypanocides with rat tissue cellular systemsen_US
dc.typeThesisen_US
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