Species and sex differences in the oxidative metabolism of cimetidine and metiamide

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dc.contributor.authorOgundahunsi, Olumide Alade
dc.date.accessioned2023-05-13T16:21:53Z
dc.date.available2023-05-13T16:21:53Z
dc.date.issued1985
dc.description149pen_US
dc.description.abstractThe oxidative metabolism of cimetidine (CM) and metiamide (MA) was investigated in seven animal species (one amphibian, two reptiles, one avian and three mammals). Both qualitative and quantitative differences in oxidative metabolism were observed for the two drugs in the different species. C-Oxidation resulting in the formation of 5-hydroxymethyl cimetidine was not detected in toads and lizards, while it was low in tortoise and rats compared to pigeon , cats and rabbits. In the metabolic conversion of CM, the urinary excretion of the sulphoxide and 5-hydroxymethyl CM was significantly different in rats of both sexes treated at two dose levels whereas for MA only the excretion of the sulphoxide metabolite was significantly different (P< 0.01). S- and C- Oxidation of both drugs were found to be dependent on the compound, animal species and their sex.en_US
dc.identifier.urihttps://ir.oauife.edu.ng/123456789/5208
dc.language.isoenen_US
dc.publisherObafemi Awolowo University, Ile Ife, Nigeriaen_US
dc.subjectMetabolismen_US
dc.subjectAnimalsen_US
dc.subjectMammalsen_US
dc.subjectOxidationen_US
dc.subjectMetabolic conversionen_US
dc.subjectSulphoxideen_US
dc.subjectMetaboliteen_US
dc.titleSpecies and sex differences in the oxidative metabolism of cimetidine and metiamideen_US
dc.typeThesisen_US
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