Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro.

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dc.contributor.authorOlayiwola, Gbola
dc.date.accessioned2019-10-08T17:20:21Z
dc.date.available2019-10-08T17:20:21Z
dc.date.issued1985
dc.description101pen_US
dc.description.abstractThe pharmacological actions of diethylcarbamazine citrate (DECC) have been examined in vitro on isolated chick biventer-cervicis muscle preparations. DECC (5x10-1 - 1.5mM) produced a concentration-related initial augmentation of the indirect electrically-evoked twitches followed by a sustained, longer-lasting secondary depression of the twitches of the skeletal muscle-nerve (chick biventer-cervicis) preparations examined. DECC-induced twitch depression was competitively reversed by increasing calcium ion (Ca ) concentration of the bathing fluid. The contractual responses of innervated chick biventor m muscle preparation induced by bathapplied low concentrations (2.5x10-2M) of carbachol, acetylcholine or nicotine was markedly augmented by DECC (10-3 - 2.5x10-2M). This same concentration of DECC (10-3 - 2.5x10- 2M)• also depressed the contra contractual responses of the muscle elicited by high concentrations of the agonists. Relatively high concentrations of DECC (10-1 - 2.5mM) dose dependently contracted isolated chick biventer cervicis muscle preparations, and demonstrated measurable anticholinesterase activity. It is concluded that DECC possesses both direct (postjunctional) and indirect (pre-junctional) effects at the neuromuscular junction, and that the neuromuscular blockade produced by DECC is possibly post-junctional in origin. The clinical significance of the neuromuscular blockade produced by DECC is also discussed.en_US
dc.identifier.citationGbola. O, 1985. Pharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro.en_US
dc.identifier.urihttps://ir.oauife.edu.ng/handle/123456789/4543
dc.language.isoenen_US
dc.publisherObafemi Awolowo Universityen_US
dc.subjectneuromuscularen_US
dc.subjectdiethylcarbamazine citrateen_US
dc.subjectpharmacological actionsen_US
dc.subjectDECCen_US
dc.subjectbiventer-cervicis muscleen_US
dc.subjectchick biventer-cervicisen_US
dc.titlePharmacological analysis of the Neuromuscular properties of Diethylcarbamazine citrate in Vitro.en_US
dc.typeThesisen_US
dc.typeThesisen_US
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