Synthesis and neuropharmacological activity of some quinoxalinone derivatives

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dc.contributor.authorOlayiwola, G.
dc.contributor.authorObafemi, C.A.
dc.contributor.authorTaiwo, F.O
dc.date.accessioned2018-11-30T18:52:26Z
dc.date.available2018-11-30T18:52:26Z
dc.date.issued2007-03-19
dc.description11en_US
dc.description.abstractEight quinoxalinone derivatives were synthesized and investigated for some neuropharmacological effects (analgesia, sedation, convulsion, anxiety, memory and psychosis) in mice and rats. In the CNS depressant activity, N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide is the most active, while the other compounds appear variously dose-dependent. Only three of the compounds showed anxiolytic effect, with N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide showing the highest activity at 2.5 mg/kg. At the dose of 30 mg/kg, 6-nitro-1,4-dihydroquinoxaline-2,3-dione showed a better anxiolytic effect in mice than diazepam (dose: 1 mg/kg), while 1,2,3,4-tetrahydroquinoxaline-2,3-dione (dose: 25 mg/kg) showed a comparative effect to diazepam. 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione and N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide showed significant anticonvulsant action. None of the compounds showed any analgesic or antidopaminergic effect. The LD50 (24 h) calculated for the compounds were between 74 and 160 mg/kg i.p.en_US
dc.identifier.citationOlayiwola et al. (2007) Synthesis and neuropharmacological activity of some quinoxalinone derivatives. African Journal of Biotechnology 6 (6):777-786en_US
dc.identifier.issn1684–5315
dc.identifier.urihttps://ir.oauife.edu.ng/handle/123456789/3735
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectQuinoxalin-2-onesen_US
dc.subjectquinoxaline-2,3-dionesen_US
dc.subjectsedative effecten_US
dc.subjectanticonvulsant activityen_US
dc.subjectanxiolytic activityen_US
dc.titleSynthesis and neuropharmacological activity of some quinoxalinone derivativesen_US
dc.typeArticleen_US
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