Polyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetable

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dc.contributor.authorTaiwo, Bamigboye
dc.contributor.authorTaiwo, Grace O.
dc.contributor.authorOlubiyi, Olujide Oludayo
dc.contributor.authorFatokun, Amos Akintayo
dc.date.accessioned2023-05-13T18:01:21Z
dc.date.available2023-05-13T18:01:21Z
dc.date.issued2016-06
dc.description25 pagesen_US
dc.description.abstractChromatographic fractionation of the methanolic extract of Corchorus olitorious (L.) (Tiliaceae), on silica gel yielded two polyphenolic compounds. The structures of the compounds were elucidated as Methyl-1,4,5-tri-O-caffeoyl quinate and Trans-3-(4-Hydroxy- 3-methoxyphenyl) acrylic anhydride, based on extensive use of spectroscopic techniques such as 1H and 13C NMR, DEPT and 2D NMR experiments (COSY, HSQC, HMBC), IR and MS. To establish an initial proof-of-concept for the biological relevance of these compounds, their cytotoxicity in the HeLa cell line was assessed as an index of their anti-tumour potential. The compounds when tested at a range of concentrations up to 1.6 mM were found to possess mild cytotoxic activity. The trans-3-(4-hydroxy-3-methoxyl phenyl) acrylic anhydride was found to be related to curcumin, a compound known to have anti-cancer activity. The plant therefore represents a source of natural ‘lead’ compounds with anti-tumour potentialen_US
dc.identifier.urihttps://ir.oauife.edu.ng/123456789/5606
dc.language.isoenen_US
dc.subjectCorchorus olitoriusen_US
dc.subjectTiliaceaeen_US
dc.subjectcaffeoyl quinateen_US
dc.subjectferrulic anhydrideen_US
dc.subjectcytotoxicityen_US
dc.titlePolyphenolic compounds with anti-tumour potential from Corchorus olitorius (L.) Tiliaceae, a Nigerian leaf vegetableen_US
dc.typeJournalen_US
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