Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine

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dc.contributor.authorAiyelabola, Temitayo
dc.contributor.authorAkinkunmi, Ezekiel Olugbenga
dc.contributor.authorObuotor, Efere Martins
dc.contributor.authorAdebajo, Adeleke Clement
dc.contributor.authorIsabirye, David
dc.date.accessioned2023-05-13T16:26:27Z
dc.date.available2023-05-13T16:26:27Z
dc.date.issued2017-02-15
dc.descriptionInternational journal of Hindawi Publisher, Volume 2017, 15 pagesen_US
dc.description.abstractEnantiomerically enriched coordination compounds of aspartic acid and racemic mixtures of coordination compounds of glycine metal-ligand ratio 1 : 3 were synthesized and characterized using infrared and UV-Vis spectrophotometric techniques and magnetic susceptibility measurements. Five of the complexes were resolved using (+)- cis -dichlorobis(ethylenediamine)cobalt(III) chloride, (+)-bis(glycinato)(1,10-phenanthroline)cobalt(III) chloride, and (+)-tris(1,10-phenanthroline)nickel(II) chloride as resolving agents. The antimicrobial and cytotoxic activities of these complexes were then determined. The results obtained indicated that aspartic acid and glycine coordinated in a bidentate fashion. The enantiomeric purity of the compounds was in the range of 22.10–32.10%, with (+)- cis -dichlorobis(ethylenediamine)cobalt(III) complex as the more efficient resolving agent. The resolved complexes exhibited better activity in some cases compared to the parent complexes for both biological activities. It was therefore inferred that although the increase in the lipophilicity of the complexes may assist in the permeability of the complexes through the cell membrane of the pathogens, the enantiomeric purity of the complexes is also of importance in their activity as antimicrobial and cytotoxic agents.en_US
dc.identifier.citationAiyelabola, Temitayo & Akinkunmi, Ezekiel Olugbenga & Ojo, Isaac & Obuotor, Efere Martins & Adebajo, Adeleke & Isabirye, David. (2017). Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine. Bioinorganic Chemistry and Applications. 2017. 1-15. 10.1155/2017/2956145en_US
dc.identifier.urihttps://ir.oauife.edu.ng/123456789/5226
dc.language.isoenen_US
dc.publisherHindawi Publishingen_US
dc.subjectSynthesesen_US
dc.subjectCharacterizationen_US
dc.subjectAspartic Aciden_US
dc.subjectGlycineen_US
dc.subjectResolutionen_US
dc.titleSyntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycineen_US
dc.typeJournalen_US
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