Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines

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dc.contributor.authorKASSIM, OLAKUNLE O.
dc.contributor.authorCOPELAND, ROBERT L.
dc.contributor.authorKENGUELE, HILAIRE M.
dc.contributor.authorNEKHAI, SERGEI
dc.contributor.authorAKO-NAI, KWASHIE A.
dc.contributor.authorKANAAN, YASMINE M.
dc.date.accessioned2023-05-13T17:49:43Z
dc.date.available2023-05-13T17:49:43Z
dc.date.issued2015-06-30
dc.description Anticancer research,Vol. 35,No. 5,p. 1453–1458en_US
dc.description.abstractBackground/Aim—Roots of Fagara zanthoxyloides and Pseudocedrela kotchyii are used as chewing sticks and as medicinal remedies for diarrhea, cough and fever in West Africa. Extracts of the two plants also possess anti-bacterial, anti-fungal and anti-malarial activities. The aim of the present study was to determine the effects of such extracts on the growth, proliferation and induction of apoptosis in four prostate cancer cell lines. Materials and Methods—Androgen-independent PC3 and DU-145 and androgen-dependent LNCaP and CWR-22 prostate cancer cell lines were cultured for five days with different concentrations of the extracts and examined for growth inhibition and evidence of apoptosis. Results—Irrespective of their androgen dependence, all four cancer cell lines exhibited a dosedependent decrease in cell proliferation and viability by the 3-[4,5-dimethylthiazol-2yl]-2,5diphenyltetrazolium bromide (MTT) assay and in induction of apoptosis. The results also show that LNCap cells were the most sensitive to the two extracts, with highest inhibition at day 3 and exhibiting the highest rate of apoptosis. Conclusion—These observations suggest that F. zanthoxyloides and P. kotchyii could serve as potential chemopreventive agents in the treatment of prostate canceren_US
dc.identifier.urihttps://ir.oauife.edu.ng/123456789/5501
dc.language.isoenen_US
dc.publisherHHS Public Accessen_US
dc.subjectPseudocedrela kotschyi.en_US
dc.subjectFagara xanthoxyloidesen_US
dc.subjectprostate canceren_US
dc.subjectAntiproliferative actionen_US
dc.titleAntiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Linesen_US
dc.typeJournalen_US
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