Electrochemical determination of serotonin in urine samples based on metal oxide nanoparticles/MWCNT on modified glassy carbon electrode
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Date
2017-01-11
Journal Title
Journal ISSN
Volume Title
Publisher
Published by Elsevier B.V
Abstract
The electrochemical response of serotonin on the modified electrode based on multiwalled-carbon-nanotube
(MWCNT) doped respectively with nickel, zinc and iron oxide nanoparticles coating on glassy carbon electrode
(GCE) at physiological pH 7 was determined using cyclic voltammetry (CV) and square wave voltammetry
(SWV). The modified GCE/MWCNT-metal oxide electrodes exhibited excellent electrocatalytic activity towards
the detection of serotonin at large peak current and lower oxidation potentials compared to other electrodes in-
vestigated. The dynamic range for the serotonin determinationwas between 5.98 × 10
−3
μM to 62.8 μMwithde-
tection limits 118, 129 and 166 nM for GCE/MWCNT-NiO, GCE/MWCNT-ZnO and GCE/MWCNT-Fe
3
O
4
sensors
respectively. GCE-MWCNT-NiO was the bestelectrode in terms of serotonin currentresponse, electrode stability,
resistance to fouling and limit of detection towards the analyte.The developed sensors were found to be electro-
chemicallystable, reusable, economically effective due to theirextremely low operational cost, and have demon-
strated good limit of detection, sensitivity and selectivity towards serotonin determination in urine samples.
© 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://
creativecommons.org/licenses/by-nc-nd/4.0/).
Description
journal of Sensing and Bio-Sensing Research, vol. 13, 17-27P.
Keywords
Metal oxides nanoparticles, Multiwalled carbon nanotubes, Glassy carbon electrode, Serotonin, Cyclic voltammetry, Square wave voltammetry