Species and sex differences in the oxidative metabolism of cimetidine and metiamide
Loading...
Date
1985
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Obafemi Awolowo University, Ile Ife, Nigeria
Abstract
The oxidative metabolism of cimetidine (CM) and metiamide (MA) was investigated in seven
animal species (one amphibian, two reptiles, one avian and three mammals).
Both qualitative and quantitative differences in oxidative metabolism were observed for the two
drugs in the different species.
C-Oxidation resulting in the formation of 5-hydroxymethyl cimetidine was not detected in toads
and lizards, while it was low in tortoise and rats compared to pigeon , cats and rabbits. In the
metabolic conversion of CM, the urinary excretion of the sulphoxide and 5-hydroxymethyl CM
was significantly different in rats of both sexes treated at two dose levels whereas for MA only
the excretion of the sulphoxide metabolite was significantly different (P< 0.01).
S- and C- Oxidation of both drugs were found to be dependent on the compound, animal species
and their sex.
Description
149p
Keywords
Metabolism, Animals, Mammals, Oxidation, Metabolic conversion, Sulphoxide, Metabolite