HIV prevention clinical trials' community engagement guidelines: inequality, and ethical conflicts.

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dc.contributor.authorFolayan, Morenike O
dc.contributor.authorPeterson, Kristin
dc.date.accessioned2024-06-13T08:13:44Z
dc.date.available2024-06-13T08:13:44Z
dc.date.issued2020-06-05T00:00:00Z
dc.description20p
dc.description.abstractIn 2004 and 2005, the first clinical trials were launched to investigate the use of tenofovir for HIV prevention in Cambodia,Cameroon, Nigeria and Thailand. Controversies erupted over the ethical integrity of the research protocol. We reflect on the events that ledto the controversies and identified that scientific and ethical concerns raised by members of local communities at each of these sites wereerased by trialists, causing crisis that led to premature shut down the early PrEP trials. In the aftermath of these trials, the World HealthOrganisation, UNAIDS, and AVAC developed ethics guidelines intended to recognize the concerns as authentic, and developed guidelines toimprove researchers' engagement of communities in biomedical HIV prevention trial design and implementation. Our findings suggest thatthe ethics guidelines are limited in its ability to address power inequalities that leads to voice erasures and non-recognition of localcompetencies. Rather the ethical documents enabled trialists to gain a new sense of authority through the interpretations of ethical researchconduct enabling trialists regain power that can further entrench inequality and voice erasures. To address concerns with what seems anintractable problem, we suggested models of engagement for off-shored research may be the option.
dc.description.sponsorshipNational Science Foundation, Science, Technology and Society, USA[grant number #0829174].
dc.identifier.citationMorenike O. Folayan & Kristin Peterson (2020) HIV prevention clinical trials’ community engagement guidelines: inequality, and ethical conflicts, Global Bioethics, 31:1, 47-66, DOI: 10.1080/11287462.2020.1773061
dc.identifier.other10.1080/11287462.2020.1773061
dc.identifier.urihttps://ir.oauife.edu.ng/handle/123456789/6520
dc.language.isoen
dc.publisherGlobal Bioethics
dc.subjectCambodia
dc.subjectCameroon
dc.subjectHIV
dc.subjectHIV prevention
dc.subjectMalawi
dc.subjectNigeria
dc.subjectPrEP
dc.subjectclinical trials
dc.subjectcommunity engagement
dc.subjectethics
dc.titleHIV prevention clinical trials' community engagement guidelines: inequality, and ethical conflicts.
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