The antibacterial activities of some organotin compounds
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Date
1985
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Obafemi Awolowo University, Ile Ife, Nigeria
Abstract
Nine derivatives of the organotin compound, tribenzyl tin-phenoxy acetate and an antibiotic
standard, ampicillin, were tested for antibacterial potency against seven bacterial species, made
up of two Gram-negative and five Gram-positive bacteria. At the screening concentration of
20mg/ml, one of the compounds, TBPA4 (Solid) - tribenzyl tin L-bromophenoxy acetale-showed
no activity against any of the test organisms, while compound TBPA3-tribenzyl L-chloro
phenoxy acetate-showed activity against only three of the organisms.
The minimum inhibitory concentrations of the active compounds were determined and one of
them, compound TBPA7-tribenzyl tin 2-nitro phenoxy acetate-showed considerable inhibitory
activity against five of the organisms at a low concentration of 1ug/ml. Of the five active
compounds that were subsequently used in the rate of killing experiments, TBPA7 again showed
the greatest activity and it compared favourably with the antibiotic standard (ampicillin).
The possibility of incorporating some of these compounds into drugs and chemotherapeutic
agents, pending further tests, is discussed
Description
93p
Keywords
Antibacterial, Organisms, Ampicillin, Bacteria, Chemotherapeutic agents, Organotin compound