Electrochemical detection of Epinephrine using Polyaniline nanocomposite films doped with TiO 2 and RuO 2 Nanoparticles on Multi-walled Carbon Nanotube
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Date
2017-05-10
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier publisher
Abstract
Electrochemical
properties
of
functionalized
MWCNT/polyaniline
doped
with
metal
oxide
(TiO
2
,
RuO
2
)
nanoparticles
were
explored.
Successful
synthesis
of
MWCNT,
TiO
2,
RuO
2
,
PANI,
MWCNT-PANI-TiO
2
,
and
MWCNT-PANI-RuO
2
nano
materials
were
confirmed
using
suitable
characterization
techniques.
Successful
modification
of
gold
(Au)
electrode
with
these
nanoparticles
was
confirmed
using
electrochemical
techniques
such
as
cyclic
voltammetry
(CV)
and
electrochemical
impedance
spectroscopy.
Au-MWCNT-PANI-TiO
2
and
Au-MWCNT-PANI-RuO
2
gave
the
best
electron
transport
properties
towards
the
oxidation
of
epinephrine
(EP)
compared
with
other
electrodes
investigated.
The
Tafel
values
0.448
and
0.442
V/decade
for
Au-MWCNT-PANI-TiO
2
and
Au-MWCNT-PANI-RuO
2
electrodes
respectively
in
(EP)
suggest
adsorption
due
to
analyte
oxidation
intermediates
products.
The
linear
calibration
plot
was
obtained
for
EP
at
concentrations
range
4.9
to
76.9
m
M.
The
limits
of
detection
of
EP
were
estimated
to
be
0.16
and
0.18
m
M
for
Au-MWCNT-PANI-TiO
2
and
Au-MWCNT-PANI-RuO
2
electrodes
respectively.
The
interference
study
using
DPV
showed
clear
peak
separation
for
amino
acid
(AA)
and
EP.
Therefore,
the
modified
electrodes
can
selectively
detect
epinephrine
without
interference
from
ascorbic
acid
signal.
The
analytical
performance
of
the
fabricated
sensors
has
been
evaluated
for
detection
of
epinephrine
(EP)
in
a
pharmaceutical
sample
with
satisfactory
results
Description
International journal of Elsevier publishing, 335p.
Keywords
Electrocatalysis, epinephrine, polyaniline composite, TiO 2 and RuO 2 nanoparticles, multiwalled carbon nanotube