Correlation of anthropometric parameters with serum luteinizing hormone and progesterone levels for the prediction of ovulation in infertile women in Ile-Ife, Nigeria
No Thumbnail Available
Date
2024
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Department of Physiological Sciences, Faculty of basic medical sciences, Obafemi Awolowo University, Ile-Ife.
Abstract
This study assessed the anthropometry parameters such as body mass index (BMI), waist-hip ratio (WHR), waist-height ratio (WHtR), neck circumference (NC) and cormic index (CI) in infertile and fertile women, measured serum levels of luteinizing hormone (LH) and progesterone (P4) in infertile and fertile women, correlated BMI, WHR, WHtR, NC and CI with Day 3 serum LH levels, and correlated BMI, WHR, WHtR, NC and CI with mid-luteal serum P4 levels. These were with a view to providing information on the possible correlation between maternal anthropometric parameters and the established clinical hormonal levels in predicting ovulation in infertile women. The Research and Ethics Committee of the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, granted ethical approval for this study (ERC/2024/04/11). Sixty women were equally assigned into three groups of 20 women each: Group I- Anovulatory infertile women, Group II- Ovulatory infertile women, and Group III- Fertile women controls. The anthropometric parameters such as BMI, CI, WHR, WHtR, NC and triceps skinfold thickness (TSF) were measured and recorded twice for all the women- on days 3 and 21 of their menstrual cycles. On days 3 and 21 of their menstrual cycles, 5 ml of venous blood was obtained from all the women and analysed in the Chemical Pathology laboratory, OAUTHC, to determine the LH and P4 levels, respectively. Serum levels of LH and P4 in the blood samples were determined using the iChroma autoanalyzer (Boditech Med Inc., Republic of Korea). Correlation of anthropometric parameters with serum levels of P4 and LH was carried out with Pearson correlation coefficient. The Receiver Operating Characteristic (ROC) curve was utilised to determine the critical values of BMI, CI, WHR, WHtR, TSF, and NC for the prediction of ovulation. A P value < 0.05 determined statistical significance. The results showed that there were no significant differences between day 3 and day 21 anthropometric measurements of BMI (26.56 ± 6.26 kg/m2vs. 26.56 ± 6.26 kg/m2; P= 0.999), CI (44.75 ± 3.21 vs. 44.75 ± 3.21; P= 1.000), WHR (0.86 ± 0.07 vs. 0.86 ± 0.07; P= 0.969), WHtR (0.55 ± 0.08 vs. 0.55 ± 0.08; P= 0.991), NC (34.01 ± 4.10 cm vs. 34.01 ± 4.10 cm; P= 0.995), and TSF (7.92 ± 2.90 cm vs. 7.92 ± 2.91 cm; P= 0.990). Body mass index (r= 0.035), CI (r= 0.047), WHtR (r= 0.023), TSF (r= 0.028), WHR (r= -0.029) and NC (r= -0.029) had weak correlations with day 3 LH. Mid-luteal P4 had significant moderate negative correlations with BMI (r= -0.434) and WHtR (r= -0.346), and weak correlations with CI (r= 0.186), WHR (r= -0.009), NC (r= -0.241) and TSF (r= -0.060). Cormic index correlated significantly with WHtR (r= 0.265). A CI of ≤ 43.6 was the best predictor of ovulation with an Area Under the Curve (AUC) of 0.659, and a sensitivity of 78.8%. A WHR of ≤ 0.83 was the second most accurate predictor of ovulation with an AUC of 0.559, and a sensitivity of 77.8%.
The study concluded that cormic index could potentially be used alone, or in combination with waist-hip ratio and waist-height ratio, to predict ovulation amongst infertile wome
Description
xviii, 105p.
Keywords
Citation
Akaninyene, E. U. (2024). Correlation of anthropometric parameters with serum luteinizing hormone and progesterone levels for the prediction of ovulation in infertile women in ile-Ife, Nigeria. Department of Physiological Sciences, Faculty of basic medical sciences, Obafemi Awolowo University, Ile-Ife.