Master of Science (M.Sc.) Theses and Dissertations

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    Open Access
    Perceived efficacy and utilisation of modern topical wound dressing agents among nurse in healthcare facilities in osun state, Nigeria
    (Department of Nursing Science, Obafemi Awolowo Unversity, 2023) Mustapha, Foluke Toyin
    This study assessed nurses’ perception of modern topical wound dressing agents (MTWDAs) in selected hospitals in Osun State; explored the level and context of use of MTWDAs among nurses;assessed the perceived efficacyof MTWDAs among nurses and identified factors influencing the utilisation of MTWDAs among nurses. These were with the view to providing empirical facts on perceived efficacy and level of utilisation of MTWDAs among nurses in Osun State.The study adopted a sequential explanatory mixed methods design. Purposive sampling technique was adopted to select the study setting. The settings of the study were Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Osun State University Teaching Hospital (UNIOSUNTH), Osogbo, State Hospital, Oke Ogbo, Ile-Ife and State Specialist Hospital, Asubiaro, Osogbo, Osun State. Ethical approvals were obtained from each of the health facilities, and informed consent obtained from each participant. Considering the small population of the nurses in selected units, all the nurses available in the units where wound care is regularly done participated in the study. A total of one hundred and eighty-four nurses were used for the quantitative phase of the study, while thirteen key informants that were purposively selected participated in the qualitative phase. Data were collected with the aid of a pretested structured questionnaire and a key informant interview schedule. Quantitative data were analysed using percentages, Pearson Chi-Square, and Multinomial logistic regression, while analysis of the qualitative data was done with content analysis. Hypotheses were tested with alpha value set at p < 0.05. The results showed that 53.8% of the nurses had a negative perception of MTWDAs, while 46.2% had a positive perception. The qualitative results yielded the various reasoning that informed both the negative perception of MTWDAs and the positive perception. A serendipitous finding of the study was the discovery of poor awareness/inadequate xviknowledge of MTWDAs, particularly among the State Hospital nurses. Results further revealed that 44.0% of the nurses reported high use of MTWDAs, 41.8% moderate use and 14.2% low use. There was however no significant relationship between the nurses’ perception of MTWDAs and their level of use of these agents (χ2 = 2.13; p = 0.34). Analysis of the narrative from informants revealed no clear cut pattern of use, and the level of use was basically relative to the context of use; mainly on infected wounds. Furthermore, results showed that 52.7% had high perceived efficacy of MTWDAs, 17.9% recorded moderate perceived efficacy, while 29.4% had low perceived efficacy.There was significant association between perceived efficacy and utilisation of modern topical wound dressing agents (χ2= 10.608; p = 0.031). Prominent among factors identified as influencing the utilisation of MTWDAs in this study werenurses’ knowledge of current trend in wound care (95.3%); nature of the wound (95.1%); and frequency of dressing change (87.0%). The study therefore concluded that despite the negative perception and inadequate knowledge of modern topical wound dressing agents, there was a high perceived efficacy and moderate use of the dressing agents among nurses in the study settingThis study assessed nurses’ perception of modern topical wound dressing agents (MTWDAs) in selected hospitals in Osun State; explored the level and context of use of MTWDAs among nurses;assessed the perceived efficacyof MTWDAs among nurses and identified factors influencing the utilisation of MTWDAs among nurses. These were with the view to providing empirical facts on perceived efficacy and level of utilisation of MTWDAs among nurses in Osun State.The study adopted a sequential explanatory mixed methods design. Purposive sampling technique was adopted to select the study setting. The settings of the study were Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Osun State University Teaching Hospital (UNIOSUNTH), Osogbo, State Hospital, Oke Ogbo, Ile-Ife and State Specialist Hospital, Asubiaro, Osogbo, Osun State. Ethical approvals were obtained from each of the health facilities, and informed consent obtained from each participant. Considering the small population of the nurses in selected units, all the nurses available in the units where wound care is regularly done participated in the study. A total of one hundred and eighty-four nurses were used for the quantitative phase of the study, while thirteen key informants that were purposively selected participated in the qualitative phase. Data were collected with the aid of a pretested structured questionnaire and a key informant interview schedule. Quantitative data were analysed using percentages, Pearson Chi-Square, and Multinomial logistic regression, while analysis of the qualitative data was done with content analysis. Hypotheses were tested with alpha value set at p < 0.05. The results showed that 53.8% of the nurses had a negative perception of MTWDAs, while 46.2% had a positive perception. The qualitative results yielded the various reasoning that informed both the negative perception of MTWDAs and the positive perception. A serendipitous finding of the study was the discovery of poor awareness/inadequate xviknowledge of MTWDAs, particularly among the State Hospital nurses. Results further revealed that 44.0% of the nurses reported high use of MTWDAs, 41.8% moderate use and 14.2% low use. There was however no significant relationship between the nurses’ perception of MTWDAs and their level of use of these agents (χ2 = 2.13; p = 0.34). Analysis of the narrative from informants revealed no clear cut pattern of use, and the level of use was basically relative to the context of use; mainly on infected wounds. Furthermore, results showed that 52.7% had high perceived efficacy of MTWDAs, 17.9% recorded moderate perceived efficacy, while 29.4% had low perceived efficacy.There was significant association between perceived efficacy and utilisation of modern topical wound dressing agents (χ2= 10.608; p = 0.031). Prominent among factors identified as influencing the utilisation of MTWDAs in this study werenurses’ knowledge of current trend in wound care (95.3%); nature of the wound (95.1%); and frequency of dressing change (87.0%). The study therefore concluded that despite the negative perception and inadequate knowledge of modern topical wound dressing agents, there was a high perceived efficacy and moderate use of the dressing agents among nurses in the study setting.
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    Open Access
    Evaluation of serum free light chains as markers of disease severity in patients with chronic lymphocytic leukamia in southwestern Nigeria.
    (Department of Haematology and Immunlogy, Faculty of Basic Medical Science, Obafemi Awolowo University., 2022) GBOTOSHO Olabisi Abosede
    The aim of this study is to determine the haematological parameters, disease severity, serum lactate dehydrogenase, serum β2 microglobulin, serum creatinine and serum free light chains kappa and lambda of newly diagnosed CLL patients; and assess the relationship between the pattern of free light chains and the measured parameters, with the view to improve treatment of chronic lymphocytic leukemia patients. Thirty-three newly diagnosed CLL patients were enrolled into the study using convenience sampling method. Patients with other chronic illnesses or in disease transformation were excluded. Ethical approval was obtained from the National Health Research Ethics Committee of Nigeria. Data on socio-demographic characteristics, general physical and systemic examination was also collected for each eligible patient, after informed consent was obtained. Clinical disease severity score was determined using the Binet staging system. Ten milliliters of venous blood were collected; 5ml were anticoagulated using EDTA to obtain haematological parameters from an haemo-autoanalyzer; and for making peripheral blood film using standard operating procedures. The remaining 5ml of blood was dispensed into a plain bottle to obtain serum using standard operating procedures. The sera collected were stored at -200C and batch tested for serum free light chains, kappa and lambda, from which the kappa/lambda ratio was calculated, β2-microglobulin, lactate dehydrogenase (LDH) and creatinine. Numerical values were reported as frequency, percentage, median, interquartile range, minimum and maximum values. Bivariate analysis was used for continuous variables while chi-square test was used for non-continuous variables data. A p-value ≤ 0.05 or 95% CI (CI=95%) was defined as statistical significance