Synthesis and characterization of poly-5- dimethylaminouridylic acid

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dc.contributor.authorAkindahunsi, Afolabi Akintunde
dc.date.accessioned2023-05-13T16:28:07Z
dc.date.available2023-05-13T16:28:07Z
dc.date.issued1985
dc.description66pen_US
dc.description.abstractThe bromination of uridine monophosphate (UMP) with Br2 in dry formamide gave 5- bromouridine monophosphate (Br5UMP), which by reaction with dimethylamine was converted into 5-dimethylaminouridine monophosphate (Me2N5UMP). This was treated with phosphoric acid by the phosphoromorpholidate method to afford 5-dimethylaminouridine -5'-diphosphate (Me2N5UDP). Poly 5-dimethylaminouridylic acid, otherwise known as Poly (Me2N5U) was prepared by polymerization of 5-dimethylaminouridine diphosphate (Me2N5UDP) with polynucleotide phosphorylase (PNPase). The polymer formed a 1:1 hybrid with polyadenylic acid (Poly A).en_US
dc.identifier.urihttps://ir.oauife.edu.ng/123456789/5242
dc.language.isoenen_US
dc.publisherObafemi Awolowo University, Ile Ife, Nigeriaen_US
dc.subjectBrominationen_US
dc.subjectPolymerizationen_US
dc.subjectUridine monophosphateen_US
dc.subjectAciden_US
dc.titleSynthesis and characterization of poly-5- dimethylaminouridylic aciden_US
dc.typeThesisen_US
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