Synthesis, characterisation and antimicrobial activity of mental (11) complexes of (E)-N'-(4-phenylbutan 2-ylidene) isonicotinohydrazones and their mixed ligand complexes.
| dc.contributor.author | OGUNSAKIN, Olanike Esther. | |
| dc.date.accessioned | 2025-09-03T11:52:22Z | |
| dc.date.available | 2025-09-03T11:52:22Z | |
| dc.date.issued | 2022 | |
| dc.description | xxiii, 225p. | |
| dc.description.abstract | This study synthesised hydrazide-hydrazone metal(II) complexes, its derivatives, along with the mixed ligand complexes with N,N’-chelating ligands, characterised the synthesised compounds and their metal complexes, carried out an in silico studies of the ligands and their metal complexes and also determined the antimicrobial activity the synthesised compounds and their metal complexes. These were with a view to establishing the geometry and antimicrobial activity compounds against some selected strains of microorganisms. The ligands (E)-N´-(4-Phenylbutan-2-ylidene) isonicotinohydrazone(L1) and (Z)-3-hydroxy-N´-(4-phenylbutan-2-ylidene)-2-naphthohydrazone(L2) were synthesized by adding ethanolic solution of isonicotinic acid hydrazide and 3,2-napthoic hydrazide on ethanolic solution of 4-phenyl-butan-2-one in the ratio of 1:1 and then refluxed at 80 oC for 6 hours. Metal complexes of the ligands were synthesized by reacting ethanolic solution of the chloride salts of the metal with ethanoic solution of the ligands in the ratio 1:2 and the mixture stirred for one hour, precipitates formed were washed with ethanol and dried over calcium chloride in a desiccator. The mixed ligand complexes of these ligands were carried out by reacting ethanoic solution of metal chloride salts to a stirring ethanolic solution of the hydrazide-hydrazone as the primary ligand and then adding ethanolic solution of N,N'-chelating ligand as the secondary ligand in 1:1 molar ratio. These compounds were characterised using physicochemical parameters, infra-red and uv-visible spectroscopy, elemental analysis, conductivity and magnetic susceptibility measurements. Antimicrobial screening of the compounds was investigated against two Gram-positive bacteria and two Gram-negative bacteria using the cup-plate agar diffusion and the microbroth dilution techniques to determine the minimum inhibitory concentration and minimum bactericidal concentration. The molecular docking studies were carried out using the Molegro Virtual Docker to predict the most probable kind of interactions, binding affinity and ligand orientation of these compounds at the active site of the selected proteins. The complexes displayed varying colours ranging from green to yellow with high melting points. The infra-red spectra of the ligands displayed medium bands in the range of 1588-1599 cm-1 C=N for the synthesised hydrazones and 3188,3286 cm-1 for the NH2 of the hydrazide, which shifted to a higher or lower frequency on chelation. The appearance of new weak bands at 543-659 cm-1 and 418-545 cm-1 assignable to M-O and M-N bonds indicated coordination of the ligands to metal ions. The electronic spectra of the complexes revealed intraligand transitions from π-π* and n-π*. There were d-d transitions in the visible region of the spectra, proving a strong interaction between the ligands and its complexes. The observed molar conductivities were within the range 169.21 - 172.00 Ω-1cm2mol-1 and 84.21 - 99.17 Ω-1cm2mol-1 suggesting 1:2 and 1:1 electrolytic ratio of the complexes except for [Fe(ISH)2(H2O)2]Cl3 with conductivity value of 314.19 Ω-1cm2mol-1 suggesting a 1:3. Magnetic moments studies indicated an octahedral geometry for these complexes. That is, the synthesised metal complexes displayed six coordinate geometries, while the in silico studies also revealed that these compounds exhibited a good interaction with the target proteins. The study concluded that the novel (E)-N´-(4-Phenylbutan-2-ylidene) isonicotinohydrazones, its derivatives and their mixed ligand complexes synthesised interacted in silico with target proteins and had antimicrobial activity comparable with streptomycin, hence, they could serve as precursor for drug synthesis. | |
| dc.identifier.citation | OGUNSAKIN, O.L. (2022) Synthesis, characterisation and antimicrobial activity of mental (11) complexes of (E)-N'-(4-phenylbutan 2-ylidene) isonicotinohydrazones and their mixed ligand complexes. Department of Chemistry, Faculty of Science. Obafemi Awolowo University. | |
| dc.identifier.uri | https://ir.oauife.edu.ng/handle/123456789/6758 | |
| dc.language.iso | en | |
| dc.publisher | Department of Chemistry, Faculty of Science. Obafemi Awolowo University. | |
| dc.title | Synthesis, characterisation and antimicrobial activity of mental (11) complexes of (E)-N'-(4-phenylbutan 2-ylidene) isonicotinohydrazones and their mixed ligand complexes. | |
| dc.type | Thesis |